2026
Guerrero M, Zadorozhnyi R, Lin G, Quinn CM, Calero G, Kurt-Yilmaz N, Schiffer CA, Polenova T, Gronenborn AM, Ishima R. Conformational asymmetry of human immunodeficiency virus-1 protease flaps increases along the darunavir drug resistance pathway. Protein Sci. 2026 Sep;35(9):e70736. PMID: 42554278
Krzysiak TC, Byeon IL, Ponticelli R, Lucas ME, Thompson L, DeHaven C, Thomas G, Gronenborn AM. The R203W substitution drives PACS-1 syndrome by disrupting intramolecular regulation. FEBS J. 2026 Oct;293(19):5717-5734. doi: 10.1111/febs.70492. Epub 2026 Mar 20. PMID: 41858172; PMCID: PMC13480987.
Hernández I, Byeon IL, Monnie CM, Soloshonok VA, Landa A, Oiarbide M, Gronenborn AM. Assessment of attainable distances in proteins by through-space 19F-19F couplings. Chemistry. 2026 Jul 24:e71456. doi: 10.1002/chem.71456. Epub ahead of print. PMID: 42497074.
2025
Selzer AM, Gerlach G, Gonzalez-Areizaga G, Wales TE, Cui SY, Iyer P, Engen JR, Camacho C, Ishima R, and Smithgall TE. An SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck. J Biol Chem. 2025 Jan;301(1):108088. PMID: 39675702 PMID: 39675702
Wieteska, L., Taylor, A. B, Punch, E., Coleman, J. A., Conway, I.O., Lin, Y-F., Byeon, C-H., Hinck, C.S., Krzysiak, T., Ishima, R., López-Casillas, F., Cherepanov, P., Bernard, D, Hill, C.S., and Hinck, A.P., Structures of TGF-b with betaglycan and signaling receptors reveals mechanisms of complex assembly and signaling, Nature Commun., 16(1), 1778 (2025).
White, S.E., Schwartze, T.A., Mukundan, A., Schoenherr, C., Singh, S., van Dinther, M., C., Cunningham, K., White, M. P. J., Campion, T., Pritchard, J., Hinck, C.S., ten Dijke, P., Inman, G., Maizels, R.M., and Hinck, A. P., TGM6 is a helminth secretory product that mimics TGF-b binding to TGFBR2 to antagonize signaling in fibroblasts, Nature Commun. 16(1), 1847 (2025).
Yang DT, Chong LT, Gronenborn AM. Illuminating an invisible state of the HIV-1 capsid protein CTD dimer using 19F NMR and weighted ensemble simulations. Proc Natl Acad Sci. 2025 Feb 18; 122 (8) e2420371122, https://doi.org/10.1073/pnas.2420371122 (2025).
Zhu W, Bhinderwala F, Rambo S, Gronenborn AM. Quantifying protein-drug lifetimes in human cells by 19F NMR spectroscopy. J Biomol NMR. 2025 Dec;79(4):209-219. doi: 10.1007/s10858-025-00466-x. Epub 2025 Mar 24. Erratum in: J Biomol NMR. 2025 Dec;79(4):221. doi: 10.1007/s10858-025-00473-y. PMID: 40126764.
2024
Vasyl Bondarenko, Qiang Chen, Tommy S Tillman, Yan Xu, Pei Tang, Unconventional PDZ Recognition Revealed in α7nAChR-PICK1 Complexes, ACS Chem Neurosci 15(10):2070-2079 (2024) PMC11099923
Krzysiak TC, Choi YJ, Kim YJ, Yang Y, DeHaven C, Thompson L, Ponticelli R, Mermigos MM, Thomas L, Marquez A, Sipula I, Kemper JK, Jurczak M, Thomas G, Gronenborn AM. Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification. Protein Sci. 2024 Apr;33(4):e4938. doi: 10.1002/pro.4938. PMID: 38533551; PMCID: PMC10966392.
Guseman AJ, González JJ, Yang D, Gronenborn AM. Cumulative asparagine to aspartate deamidation fails to perturb γD-crystallin structure and stability. Protein Sci. 2024 Aug;33(8):e5120. doi: 10.1002/pro.5120. PMID: 39022918; PMCID: PMC11255865.
Zhu W, Monnie CM, Kitoka K, Gronenborn AM. High-Efficiency Trifluoromethyl- Methionine Incorporation into Cyclophilin A by Cell-Free Synthesis for 19F NMR Studies. Angew Chem Int Ed Engl. 2025 Feb 10;64(7):e202419709. doi: 10.1002/anie.202419709. Epub 2024 Dec 4. PMID: 39571097; PMCID: PMC11813676
Bhinderwala F, Gronenborn AM. Exploiting 19F NMR in a Multiplexed Assay for Small GTPase Activity. J Am Chem Soc. 2025 Jan 8;147(1):1028-1033. doi: 10.1021/jacs.4c14294. Epub 2024 Dec 18. PMID: 39693054; PMCID: PMC11719398.
2023
Borgini, M., Wieteska,
Vasyl Bondarenko, Qiang Chen, Kevin Singewald, Nandan Haloi , Tommy S Tillman, Rebecca J. Howard, Erik Lindahl, Yan Xu, Pei Tang, Structural Elucidation of Ivermectin Binding to α7nAChR and the Induced Channel Desensitization, ACS Chem Neurosci 14(6): 1156-1165 (2023) PMC10020961
Zhu W, Yang DT, Gronenborn AM. Ligand-Capped Cobalt(II) Multiplies the Value of the Double-Histidine Motif for PCS NMR Studies. J Am Chem Soc. 2023 Mar 1;145(8):4564-4569. doi: 10.1021/jacs.2c12021. Epub 2023 Feb 14. PMID: 36786809.
Sarkar S, Zadrozny KK, Zadorozhnyi R, Russell RW, Quinn CM, Kleinpeter A, Ablan S, Meshkin H, Perilla JR, Freed EO, Ganser-Pornillos BK, Pornillos O, Gronenborn AM, Polenova T. Structural basis of HIV-1 maturation inhibitor binding and activity. Nat Commun. 2023 Mar 4;14(1):1237. doi: 10.1038/s41467-023-36569-y. PMID: 36871077; PMCID: PMC9985623.
2022
Xi Z, Ilina TV, Guerrero M, Fan L, Sluis-Cremer N, Wang YX, Ishima R. Relative domain orientation of the L289K HIV-1 reverse transcriptase monomer. Protein Sci. 2022. 31. E4307. PMID: 35481647
Mukundan, A., Byeon, C-H., Hinck, C. S., Cunningham, K., Campion, T., Smyth, D. J., Maizels, R. M., Hinck, A. P. Convergent evolution of a parasite-encoded CCP-scaffold to mimic binding of mammalian TGF-b to its receptors, TbRI and TbRII, J. Biol. Chem., 298, 101994-102011 (2022).
Vasyl Bondarenko, Marta M. Wells, Qiang Chen, Tommy S. Tillman, Kevin Singewald, Matthew J. Lawless, Joel Caporoso, Nicole Brandon, Jonathan A. Coleman, Sunil Saxena, Erik Lindahl, Yan Xu, Pei Tang, Structures of Highly Flexible Intracellular Domain of Human α7 Nicotinic Acetylcholine Receptor, Nat Commun, 13, 793 (2022) DOI: 10.1038/s41467-022-28400-x PMC8831596.
Zhu W, Guseman AJ, Bhinderwala F, Lu M, Su XC, Gronenborn AM. (2022) Visualizing Proteins in Mammalian Cells by 19F NMR spectroscopy. Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202201097. doi: 10.1002/anie.202201097. Epub 2022 Mar 30. PMID: 35278268; PMC9156538.
Lu M, Toptygin D, Xiang Y, Shi Y, Schwieters CD, Lipinski EC, Ahn J, Byeon IL, Gronenborn AM. (2022) The magic of linking rings: Discovery of a unique photoinduced fluorescent protein crosslink. J Am Chem Soc.2022 Jun 22;144(24):10809-10816. doi: 10.1021/jacs.2c02054. Epub 2022 May 14. PMID: 35574633; PMC9233106